Dilantin (Dilantin)100mg – 100 tablet

Phenytoin Information

Pronunciation

FEN i toyn

What is this drug used for?

• It is used to help control certain kinds of seizures.

• It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

• Fatigue

• Headache

• Anxiety

• Trouble sleeping

• Constipation

• Vomiting

• Change in taste

• Nausea

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Infection

• Stevens-Johnson syndrome/toxic epidermal necrolysis like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in mouth, throat, nose, or eyes

• Depression like thoughts of suicide, anxiety, emotional instability, agitation, irritability, panic attacks, mood changes, behavioral changes, or confusion

• High blood sugar like confusion, fatigue, increased thirst, increased hunger, passing a lot of urine, flushing, fast breathing, or breath that smells like fruit

• Change in balance

• Abnormal gait

• Confusion

• Slurred speech

• Gingival pain or swelling

• Severe muscle pain

• Abnormal movements

• Twitching

• Trouble swallowing

• Trouble speaking

• Severe loss of strength and energy

• Seizures

• Burning or numbness feeling

• Bruising

• Bleeding

• Bone pain

• Involuntary eye movements

• Tremors

• Swollen glands

• Fever

• Rash

• Chest pain

• Unable to pass urine

• Change in amount of urine passed

• Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin

• Fast heartbeat

• Slow heartbeat

• Abnormal heartbeat

• Severe dizziness

• Passing out

• Severe injection site redness, swelling, pain, or irritation

• Skin discoloration

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Medication Safety Issues

Storage and Stability

Capsule, tablet: Store at 20°C to 25°C (68°F to 77°F). Protect capsules from light. Protect capsules and tablets from moisture.

Oral suspension: Store at 20°C to 25°C (68°F to 77°F); do not freeze. Protect from light.

Solution for injection: Store at 15°C to 30°C (59°F to 86°F). Use only clear solutions free of precipitate and haziness; slightly yellow solutions may be used. Precipitation may occur if solution is refrigerated and may dissolve at room temperature. Discard any unused product.

Adverse Reactions

Cardiovascular: Cardiac arrhythmia, cardiac conduction disturbance (depression), circulatory shock, hypotension, ventricular fibrillation

Central nervous system: Ataxia, cerebral atrophy (elevated serum levels and/or long-term use), cerebral dysfunction (elevated serum levels and/or long-term use), confusion, dizziness, drowsiness, headache, insomnia, nervousness, paresthesia, peripheral neuropathy (associated with chronic treatment), slurred speech, suicidal ideation, suicidal tendencies, twitching, vertigo

Dermatologic: Bullous dermatitis, exfoliative dermatitis, morbilliform rash, scarlatiniform rash, skin or other tissue necrosis, skin rash

Endocrine & metabolic: Decreased T4, increased gamma-glutamyl transferase, vitamin D deficiency (associated with chronic treatment)

Gastrointestinal: Constipation, dysgeusia, gingival hyperplasia, nausea, swelling of lips, vomiting

Genitourinary: Peyronie’s disease

Hematologic & oncologic: Macrocytosis, megaloblastic anemia, pseudolymphoma, purpuric dermatitis

Hepatic: Acute hepatic failure, hepatic injury, hepatitis, increased serum alkaline phosphatase, toxic hepatitis

Local: Injection site reaction (“purple glove syndrome;” edema, discoloration, and pain distal to injection site), local inflammation, local irritation, localized tenderness, local tissue necrosis

Neuromuscular & skeletal: Osteomalacia

Ophthalmic: Nystagmus

Miscellaneous: Fever, tissue sloughing –